Open Access

A Review on Different Types of Nanoparticles Synthesized from Azadirachta indica and Gymnema sylvestre and their Role in Combating Various Diseases

Yashfeen Ansari , ansariyashfeen10@gmail.com
Department of Biotechnology, School of Life Science and Technology, IIMT University, Meerut, UP, India
Navneet Sharma navneet.sh15@gmail.com
Department of Biotechnology, School of Life Science and Technology, IIMT University, Meerut, UP, India
ORCID



J. Environ. Nanotechnol., Volume 14, No 3 (September 2025) pp. 523-539

https://doi.org/10.13074/jent.2025.09.2521564

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Abstract

The core function of nanotechnology is to generate nanoparticles in a sophisticated and environmentally responsible manner. An advanced field of nanobiotechnology is developed when nanotechnology and biology are combined. Nanoparticles (NPs) exhibit distinct properties making them valuable in a wide range of life science applications. In response to the concerning levels of toxic substances in the environment, researchers have come up with green techniques that harness the properties of plants, fungi, bacteria, and algae for the production of nanoparticles. It has been determined that these environmentally friendly techniques are safer than the physical and chemical methods. Biosynthesized nanoparticles have a wide range of applications. One of the most important applications is their role in herbal medicine. This comprehensive review focuses on different types of nanoparticles green synthesized through the utilization of leaf extracts from Azadirachta indica and Gymnema sylvestre and their effect as herbal nano-medicine. Nanoparticles are known to increase the bioavailability, stability and targeted delivery of the bioactive compounds, thus improving the remedial outcomes and reducing the possible side effects. These two well-known herbs, A. indica and G. sylvestre have been widely used in nano-herbal medicines. They are used to produce nanoscale formulations which have proved enhanced bioavailability and improved pharmacological effects. Numerous diseases including diabetes and cancer are being offered novel solutions through the use of nano-herbal means extracted from these plants.

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Reference


Abdelhakim, H. K., El‐Sayed, E. R. and Rashidi, F. B., Biosynthesis of zinc oxide nanoparticles with antimicrobial, anticancer, antioxidant and photocatalytic activities by the endophytic Alternaria tenuissima, J. Appl. Microbiol., 128(6), 1634–1646(2020).

https://doi.org/10.1111/jam.14581

Abid, N., Khan, A. M., Shujait, S., Chaudhary, K., Ikram, M., Imran, M., and Maqbool, M., Synthesis of nanomaterials using various top-down and bottom-up approaches, influencing factors, advantages, and disadvantages: A review. Advances in colloid and interface science, 300, 102597 (2022).

Abuzeid, H. M., Julien, C. M., Zhu, L. and Hashem, A. M., Green synthesis of nanoparticles and their energy storage, environmental, and biomedical applications, Cryst., 13(11), 1576(2023).

https://doi.org/10.3390/cryst13111576

Al-Aboody, A. M. S., Silver/silver chloride (Ag/AgCl) nanoparticles synthesized from Azadirachta indica latex and its antibiofilm activity against fluconazole-resistant Candida tropicalis. Artif, Cells. Nanomed. Biotechnol., 47(1), 2107–2113(2019).

https://doi.org/10.1080/21691401.2019.1620257

Algebaly, A. S., Mohammed, A. E., Abutaha, N. and Elobeid, M. M., Biogenic synthesis of silver nanoparticles: Antibacterial and cytotoxic potential, Saudi. J. Biol. Sci., 27(5), 1340–1351(2020).

https://doi.org/10.1016/j.sjbs.2019.12.014

Alharbi, N. S. and Alsubhi, N. S., Silver nanoparticles biosynthesized using Azadirachta indica fruit and leaf extracts: Optimization, characterization, and anticancer activity, J. Nanomater., 2023, 1-17(2023).

https://doi.org/10.1155/2023/9916777

Alvi, G. B., Iqbal, M. S., Ghaith, M. M. S., Haseeb, A., Ahmed, B. and Qadir, M. I., Biogenic selenium nanoparticles (SeNPs) from citrus fruit have antibacterial activities, Sci. Rep., 11(1), 4811(2021).

https://doi.org/10.1038/s41598-021-84099-8

Alzohairy, M. A., Therapeutic role of Azadirachta indica (Neem) and their active constituents in disease prevention and treatment, Evidence-Based. Complemendry. Altern. Med., 2016(1), 7382506(2016).

https://doi.org/10.1155/2016/7382506

An, H., Deng, X., Wang, F., Xu, P. and Wang, N., Dendrimers as nanocarriers for the delivery of drugs obtained from natural products, Polym., 15(10), 2292(2023).

https://doi.org/10.3390/polym15102292

Ansari, M. A., Murali, M., Prasad, D., Alzohairy, M. A., Almatroudi, A., Alomary, M. N., Udayashankar, A. C., Singh, S. B., Asiri, S. M. M., Ashwini, B. S., Gowtham, H. G., Nataraj, K., Kestur, N. A., Thimappa, R. L. and Siddapura, R. N., Cinnamomum verum bark extract mediated green synthesis of ZnO nanoparticles and their antibacterial potentiality, Biomol., 10(2), 336(2020).

https://doi.org/10.3390/biom10020336

Ao, W., Li, J., Yang, H., Zeng, X. and Ma, X., Mechanochemical synthesis of zinc oxide nanocrystalline, Powder. Technol., 168(3), 148–151(2006).

https://doi.org/10.1016/j.powtec.2006.07.014

Arunachalam, K. D., Arun, L. B., Annamalai, S. K. and Arunachalam, A. M., Potential anticancer properties of bioactive compounds of Gymnema sylvestre and its biofunctionalized silver nanoparticles, Int. J. Nanomed., 10, 31–41(2015).

https://doi.org/10.2147/ijn.s71182

Avinash, B., Venu, R., Prasad, T. N., Alpha Raj, M., Srinivasa Rao, K. and Srilatha, C., Synthesis and characterization of neem leaf extract, 2,3-dehydrosalanol, and quercetin dihydrate mediated silver nanoparticles for therapeutic applications, IET. Nanobiotechnol., 11(4), 383–389(2017).

https://doi.org/10.1049/iet-nbt.2016.0095

Baig, N., Kammakakam, I. and Falath, W., Nanomaterials: A review of synthesis methods, properties, recent progress, and challenges, Mater. Adv., 2(6), 1821–1871(2021).

https://doi.org/10.1039/D0MA00807A

Basnet, P., Chanu, T. I., Samanta, D. and Chatterjee, S., A review on bio-synthesized zinc oxide nanoparticles using plant extracts as reductants and stabilizing agents, J. Photochem. Photobiol. B. Biol., 183, 201–221(2018).

https://doi.org/10.1016/j.jphotobiol.2018.04.036

Bharadwaj, K. K., Rabha, B., Pati, S., Sarkar, T., Choudhury, B. K., Barman, A., Bhattacharjya, D., Srivastava, A., Baishya, D., Edinur, H. A., Noor, H. M. N. and Abdul Kari, Z., Green synthesis of gold nanoparticles using plant extracts as beneficial prospect for cancer theranostics, Mol., 26(21), 6389(2021).

https://doi.org/10.3390/molecules26216389

Bharathy, M. S., Jeyaleela, G. D., Vimala, J. D. R., Agila, A. and Sheela, S. A. M., Comparison of anti-inflammatory activities of biogenic Gymnema sylvestre- and Panicum sumatrense-mediated titanium dioxide nanoparticles, Biomed. Biotechnol. Res. J., 5(4), 405–411(2021).

http://dx.doi.org/10.4103/bbrj.bbrj_164_21

Bhoye, M., Pansambal, S., Basnet, P., Lin, K. Y. A., Gutierrez-Mercado, K. Y., Pérez-Larios, A., Chauhan, A., Oza, R. and Ghotekar, S., Eco-friendly synthesis of Ni/NiO nanoparticles using Gymnema sylvestre leaves extract for antifungal activity, J. Compos. Sci., 7(3), 105(2023).

https://doi.org/10.3390/jcs7030105

Bi, S. B., Elahi, I., Sardar, N., Ghaffar, O., Ali, H., Alsubki, R. A., Iqbal, M. S., Attia, K. A. and Abushady, A. M., Exploring non-cytotoxic, antioxidant, and anti-inflammatory properties of selenium nanoparticles synthesized from Gymnema sylvestre and Cinnamon cassia extracts for herbal nanomedicine, Microb. Pathog., 192, 106670(2024).

https://doi.org/10.1016/j.micpath.2024.106670

Brahmachari, G. Neem—an omnipotent plant: A retrospection, Chembiochem., 5(4), 408–421(2004).

https://doi.org/10.1002/cbic.200300749

Chandra, H., Kumari, P., Bontempi, E. and Yadav, S., Medicinal plants: Treasure trove for green synthesis of metallic nanoparticles and their biomedical applications, Biocatal. Agric. Biotechnol., 24, 101518(2020).

https://doi.org/10.1016/j.bcab.2020.101518

Charaka, Charaka Samhita, Varanasi: Chaukhamba Orientalia (1981).

Chaurasia, R., Agrawal, O., Bansal, S. and Mukherjee, M., Green nanostructures: Biomedical applications and toxicity studies, Bioinspired. Green. Synth. Nanostruct., 307–324(2023).

http://dx.doi.org/10.1002/9781394174928.ch13

Chavan, A. B., Goyal, S. and Patel, A. M., Formulation of silver nanoparticles using Gymnema sylvestre leaf extract and in-vitro anti-diabetic activity, J. Pharm. Res. Int., 34, 39–49(2022).

https://doi.org/10.9734/jpri/2022/v34i7A35450

Chen, D., Jiao, X. and Cheng, G., Hydrothermal synthesis of zinc oxide powders with different morphologies, Solid. Stat. Commun., 113(6), 363–366(1999).

https://doi.org/10.1016/S0038-1098(99)00472-X

Chen, T., Wong, Y. S., Zheng, W., Bai, Y. and Huang, L., Selenium nanoparticles fabricated in Undaria pinnatifida polysaccharide solutions induce mitochondria-mediated apoptosis in A375 human melanoma cells, Colloid. Surf. B. Biointerface., 67(1), 26–31(2008).

https://doi.org/10.1016/j.colsurfb.2008.07.010

Cotta, M. A., Quantum dots and their applications: What lies ahead?, ACS. Appl. Mater. Interface., 3(6), 4920–4924(2020).

https://doi.org/10.1021/acsanm.0c01386

Demissie, M. G., Sabir, F. K., Edossa, G. D. and Gonfa, B. A., Synthesis of zinc oxide nanoparticles using leaf extract of Lippia adoensis (koseret) and evaluation of its antibacterial activity, J. Chem., 2020(1), 7459042(2020).

https://doi.org/10.1155/2020/7459042

Devi, M. S., Srinivasan, S. and Muthuvel, A., Selenium nanomaterial is a promising nanotechnology for biomedical and environmental remediation: A detailed review, Biocatal. Agric. Biotechnol., 51, 102766(2023).

https://doi.org/10.1016/j.bcab.2023.102766

Dhandapani, P., Maruthamuthu, S. and Rajagopal, G., Bio-mediated synthesis of TiO₂ nanoparticles and its photocatalytic effect on aquatic biofilm, J. Photochem. Photobiol. B.Biol., 110, 43–49(2012).

https://doi.org/10.1016/j.jphotobiol.2012.03.003

Dobrucka, R. and Długaszewska, J., Biosynthesis and antibacterial activity of ZnO nanoparticles using Trifolium pratense flower extract, Saudi. J. Biol. Sci., 23(4), 517–523(2016).

https://doi.org/10.1016/j.sjbs.2015.05.016

El-Beltagi, H. S., Ragab, M., Osman, A., El-Masry, R. A., Alwutayd, K. M., Althagafi, H., ... & El-Saber, M. M.. Biosynthesis of zinc oxide nanoparticles via neem extract and their anticancer and antibacterial activities. PeerJ, 12, e17588 (2024).

Elumalai, K. and Velmurugan, S., Green synthesis, characterization and antimicrobial activities of zinc oxide nanoparticles from the leaf extract of Azadirachta indica (L.), Appl. Surf. Sci., 345, 329–336(2015).

http://dx.doi.org/10.1016/j.apsusc.2015.03.176

Gotteparthi, S., Manvitha, K. D. S. and Sridevi, K., Evaluation of Anti-Diabetic Activity of Zinc Oxide Nanoparticles of Gymnema sylvestre Extract on Wistar Rats, J. Drug. Delivery. Ther., 13(11), 31-38(2023).

http://dx.doi.org/10.22270/jddt.v13i11.6283

Hashem, A. H., Abdelaziz, A. M., Askar, A. A., Fouda, H. M., Khalil, A. M., Abd-Elsalam, K. A. and Khaleil, M. M., Bacillus megaterium-mediated synthesis of selenium nanoparticles and their antifungal activity against Rhizoctonia solani in faba bean plants, J. Fungi., 7(3), 195(2021).

https://doi.org/10.3390/jof7030195

Hassanin, K. M., El-Kawi, S. H. A. and Hashem, K. S., The prospective protective effect of selenium nanoparticles against chromium-induced oxidative and cellular damage in rat thyroid, Int. J. Nanomed., 8, 1713–1720(2013).

https://doi.org/10.2147/ijn.s42736

Hawadak, J., Kojom Foko, L. P., Pande, V. and Singh, V., In vitro antiplasmodial activity, hemocompatibility and temporal stability of Azadirachta indica silver nanoparticles. Artif. Cells, Nanomed. Biotechnol., 50(1), 286–300(2022).

http://dx.doi.org/10.1080/21691401.2022.2126979

Hawsah, M. A., Abdel-Gaber, R., Al-Quraishy, S., Aljawdah, H. M., Maodaa, S. N. and Al-Shaebi, E., Green synthesis of selenium nanoparticles using Azadirachta indica leaves extract: Evaluation of anthelmintic and biocompatibility potential, Food. Sci. Technol., 43, 1-6(2023).

https://doi.org/10.5327/fst.13223

Hosnedlova, B., Kepinska, M., Skalickova, S., Fernandez, C., Ruttkay-Nedecky, B., Peng, Q., Baron, M., Melcova, M., Opatrilova, R., Zidkova, J., Jiri, S., Rene, K. and Bjørklund, G., Nano-selenium and its nanomedicine applications: A critical review, Int. J. Nanomed, 13, 2107–2128(2018).

https://doi.org/10.2147/ijn.s157541

Hossain, N., Mobarak, M. H., Mimona, M. A., Islam, M. A., Hossain, A., Zohura, F. T. and Chowdhury, M. A., Advances and significances of nanoparticles in semiconductor applications–A review, Results. Eng., 19, 101347(2023).

https://doi.org/10.1016/j.rineng.2023.101347

Huang, B., Zhang, J., Hou, J. and Chen, C., Free radical scavenging efficiency of Nano-Se in vitro, Free. Radic. Biol. Med., 35(7), 805–813(2003).

https://doi.org/10.1016/s0891-5849(03)00428-3

Huang, X., Chen, X., Chen, Q., Yu, Q., Sun, D. and Liu, J., Investigation of functional selenium nanoparticles as potent antimicrobial agents against superbugs, Acta. Biomater., 30, 397–407(2016).

https://doi.org/10.1016/j.actbio.2015.10.041

Huang, Y., He, L., Liu, W., Fan, C., Zheng, W., Wong, Y. S. and Chen, T., Selective cellular uptake and induction of apoptosis of cancer-targeted selenium nanoparticles, Biomater., 34(29), 7106–7116(2013).

https://doi.org/10.1016/j.biomaterials.2013.04.067

Ibrahim, H. M. M., Green synthesis and characterization of silver nanoparticles using banana peel extract and their antimicrobial activity against representative microorganisms, J. Radiat. Res. Appl. Sci., 8(3), 265–275(2015).

https://doi.org/10.1016/j.jrras.2015.01.007

Iqbal, J., Abbasi, B. A., Yaseen, T., Zahra, S. A., Shahbaz, A., Shah, S. A., Uddin, S., Ma, X., Raouf, B., Kanwal, S., Tariq, M., Hamed, A. E., Parvaiz, A. and Amin, W., Green synthesis of zinc oxide nanoparticles using Elaeagnus angustifolia L. leaf extracts and their multiple in vitro biological applications, Sci. Rep., 11, 20988(2021).

https://doi.org/10.1038/s41598-021-99839-z

Iravani, S., Green synthesis of metal nanoparticles using plants, Green Chem., 13(10), 2638–2650(2011).

https://doi.org/10.1039/C1GC15386B

Irshad, S., Salamat, A., Anjum, A. A., Sana, S., Saleem, R. S., Naheed, A. and Iqbal, A., Green tea leaves mediated ZnO nanoparticles and its antimicrobial activity, Cogent. Chem., 4(1), 1469207(2018).

https://doi.org/10.1080/23312009.2018.1469207

Jadoun, S., Yáñez, J., Mansilla, H. D., Riaz, U. and Chauhan, N. P. S., Conducting polymers/zinc oxide-based photocatalysts for environmental remediation: A review, Environ. Chem. Lett., 20(3), 2063–2083(2022).

https://doi.org/10.1007/s10311-022-01398-w

Jangam, A., Tirunavalli, S. K., Adimoolam, B. M., Kasireddy, B., Patnaik, S. S., Erukkambattu, J., Thota, J. R., Andugulapati, S. B. and Addlagatta, A., Anti-inflammatory and antioxidant activities of Gymnema sylvestre extract rescue acute respiratory distress syndrome in rats via modulating the NF-κB/MAPK pathway, Inflammopharmacology, 31(2), 823–844(2023).

https://doi.org/10.1007/s10787-022-01133-5

Javed, R., Zia, M., Naz, S., Aisida, S. O., Ain, S. and Ao, Q., Role of capping agents in the application of nanoparticles in biomedicine and environmental remediation: Recent trends and future prospects, J. Nanobiotechnol., 18(1), 1–15(2020).

https://doi.org/10.1186/s12951-020-00704-4

Kadam, J., Madiwale, S., Bashte, B., Dindorkar, S., Dhawal, P. and More, P., Green mediated synthesis of palladium nanoparticles using aqueous leaf extract of Gymnema sylvestre for catalytic reduction of Cr (VI), SN. Appl. Sci., 2, 1934(2020).

https://doi.org/10.1007/s42452-020-03663-5

Kambhampati, P., Nanoparticles, nanocrystals, and quantum dots: What are the implications of size in colloidal nanoscale materials? J. Phys. Chem. Lett., 12(20), 4769–4779(2021).

https://doi.org/10.1021/acs.jpclett.1c00754

Kanetkar, P., Singhal, R. and Kamat, M., Gymnema sylvestre: A memoir, J. Clin. Biochem. Nutr., 41(2), 77–81(2007).

https://doi.org/10.3164/jcbn.2007010

Karthikeyan, M., Jafar Ahamed, A., Karthikeyan, C. and Vijaya Kumar, P., Enhancement of antibacterial and anticancer properties of pure and REM doped ZnO nanoparticles synthesized using Gymnema sylvestre leaves extract, SN. Appl. Sci., 1, 1289 (2019).

Khan, M. S., Haseeb, M., Hussain, R. A., Rehman, A. and Zubair, M., A comprehensive review on green synthesis of selenium nanoparticles and their applications, Chem. Sel., 6(30), 7430–7447(2021).

Khan, S. H., Green nanotechnology for the environment and sustainable development, In Green materials for wastewater treatment Cham, Springer. Int. Publ., 38, 13-46(2019).

https://doi.org/10.1007/978-3-030-17724-9_2

Khudier, M. A., Hammadi, H. A., Atyia, H. T., Al-Karagoly, H., Albukhaty, S., Sulaiman, G. M., Dewir, Y. H. and Mahood, H. B., Antibacterial activity of green synthesized selenium nanoparticles using Vaccinium arctostaphylos (L.) fruit extract, Cogent. Food. Agric., 9(1), 2245612(2023).

Kiranmai, M., Kazim, S. M. and Ibrahim, M., Combined wound healing activity of Gymnema sylvestre and Tagetes erecta Linn, Int. J. Pharm. Appl., 2(2), 135–140(2011).

Kitimu, S. R., Kirira, P., Abdille, A. A., Sokei, J., Ochwang’i, D., Mwitari, P., Makanya, A. and Maina, N., Anti-angiogenic and anti-metastatic effects of biogenic silver nanoparticles synthesized using Azadirachta indica, Adv. Biosci. Biotechnol., 13(4), 188–206(2022).

https://doi.org/10.4236/abb.2022.134010

Kołodziejczak-Radzimska, A., Markiewicz, E. and Jesionowski, T., Structural characterisation of ZnO particles obtained by the emulsion precipitation method, J. Nanomater., 2012, 656353(2012).

https://doi.org/10.1155/2012/656353

Kong, L., Yuan, Q., Zhu, H., Li, Y., Guo, Q., Wang, Q., Bi, X. and Gao, X., The suppression of prostate LNCaP cancer cells growth by selenium nanoparticles through Akt/Mdm2/AR controlled apoptosis, Biomater., 32(27), 6515–6522(2011).

Król, A., Pomastowski, P., Rafińska, K., Railean-Plugaru, V. and Buszewski, B., Zinc oxide nanoparticles: Synthesis, antiseptic activity and toxicity mechanism, Adv. Colloid. Interface. Sci., 249, 37–52(2017).

https://doi.org/10.1016/j.cis.2017.07.033

Kumar, K. M., Mandal, B. K., Naidu, E. A., Sinha, M., Kumar, K. S. and Reddy, P. S., Synthesis and characterisation of flower shaped zinc oxide nanostructures and its antimicrobial activity, Spectrochim. Acta. Mol. Biomol. Spectrosc., 104, 171–174(2013).

https://doi.org/10.1016/j.saa.2012.11.025

Kumar, N., Jyoti, J., Aggarwal, N., Kaur, A., Patial, P., Kaur, K., Tripathi, S., Singh, S. and Raja, V., Adsorption of Pb²⁺ using biosynthesized ZnO nanoparticles derived using Azadirachta indica (neem) leaf extract, Biomass. Convers. Biorefin., 14(23), 30601–30611(2024).

https://doi.org/10.1007/s13399-024-05419-2

Kumar, V. and Yadav, S. K., Plant-mediated synthesis of silver and gold nanoparticles and their applications, J. Chem. Technol. Biotechnol., 84(2), 151–157(2009).

http://dx.doi.org/10.1002/jctb.2023

Kumari, S. A., Patlolla, A. K. and Madhusudhanachary, P., Biosynthesis of silver nanoparticles using Azadirachta indica and their antioxidant and anticancer effects in cell lines, Micromach., 13(9), 1416(2022).

https://doi.org/10.3390/mi13091416

Lakkim, V., Reddy, M. C., Pallavali, R. R., Reddy, K. R., Reddy, C. V., Inamuddin, Bilgrami, A. L. and Lomada, D., Green synthesis of silver nanoparticles and evaluation of their antibacterial activity against multidrug-resistant bacteria and wound healing efficacy using a murine model, Antibiot., 9(12), 902(2020).

https://doi.org/10.3390/antibiotics9120902

Li, Y., Li, X., Wong, Y. S., Chen, T., Zhang, H., Liu, C. and Zheng, W., The reversal of cisplatin-induced nephrotoxicity by selenium nanoparticles functionalized with 11-mercapto-1-undecanol by inhibition of ROS-mediated apoptosis, Biomater., 32(34), 9068–9076(2011).

https://doi.org/10.1016/j.biomaterials.2011.08.001

Liang, X., Zhang, S., Gadd, G. M., McGrath, J., Rooney, D. W. and Zhao, Q., Fungal-derived selenium nanoparticles and their potential applications in electroless silver coatings for preventing pin-tract infections, Regener. Biomater, 9(1), rbac013(2022).

https://doi.org/10.1093/rb/rbac013

Madan, H. R., Sharma, S. C., Suresh, D., Vidya, Y. S., Nagabhushana, H., Rajanaik, H., Anantharaju, K. S., Prashantha, S. C. and Maiya, P. S., Facile green fabrication of nanostructure ZnO plates, bullets, flower, prismatic tip, closed pine cone: Their antibacterial, antioxidant, photoluminescent and photocatalytic properties, Spectrochim. Acta. Mol. Biomol. Spectrosc., 152, 404–416(2016).

https://doi.org/10.1016/j.saa.2015.07.067

Mahdavi, M., Namvar, F., Ahmad, M. B., Mohamad, R. and Nadi, B., Green biosynthesis and characterization of magnetic iron oxide (Fe₃O₄) nanoparticles using seaweed (Sargassum muticum) aqueous extract, Mol, 18(5), 5954–5964(2013).

https://doi.org/10.3390/molecules18055954

Manikandan, R., Beulaja, M., Thiagarajan, R., Dinesh, D. and Sangeetha, N., Green synthesis of silver nanoparticles using fruit extract of Cucumis sativus and its antibacterial potential, Int. J. Nanomed., 12, 653–661(2017).

https://doi.org/10.1155/2021/6695734

Mankad, M., Patil, G., Patel, S., Patel, D. and Patel, A., Green synthesis of zinc oxide nanoparticles using Azadirachta indica A. Juss. leaves extract and its antibacterial activity against Xanthomonas oryzae pv. Oryzae, Ann. Phytomedicine., 5, 76–86(2016).

http://dx.doi.org/10.21276/ap.2016.5.2.9

Marslin, G., Siram, K., Maqbool, Q., Selvakesavan, R. K., Kruszka, D., Kachlicki, P. and Franklin, G., Secondary metabolites in the green synthesis of metallic nanoparticles, Mater, 11(6), 940(2018).

https://doi.org/10.3390/ma11060940

Marszałł, M. P., Application of magnetic nanoparticles in pharmaceutical sciences, Pharm. Res., 28, 480–483(2011).

https://doi.org/10.1007/s11095-010-0284-6

Men, X. Y., Xu, W. G., Zhu, X. and Ma, W. C., Extraction, selenium-nanoparticle preparation and anti-virus bioactivity determination of polysaccharides from Caulerpa taxifolia, J. Chin. Med. Mater., 32(12), 1891–1894(2009).

Moghaddas, S. M. T. H., Elahi, B. and Javanbakht, V., Biosynthesis of pure zinc oxide nanoparticles using Quince seed mucilage for photocatalytic dye degradation, J. Alloys. Compd., 821, 153519(2020).

https://doi.org/10.1016/j.jallcom.2019.153519

Mustapha, T., Misni, N., Ithnin, N. R., Daskum, A. M. and Unyah, N. Z., A review on plants and microorganisms mediated synthesis of silver nanoparticles, role of plants metabolites and applications, Int. J. Environ. Res. Public. Health., 19(2), 674(2022).

https://doi.org/10.3390/ijerph19020674

Nakkala, J. R., Mata, R., Bhagat, E. and Sadras, S. R., Green synthesis of silver and gold nanoparticles from Gymnema sylvestre leaf extract: Study of antioxidant and anticancer activities, J. Nanopart. Res., 17, 1–15(2015).

https://doi.org/10.1016/j.msec.2018.05.048

Narayan, N., Meiyazhagan, A. and Vajtai, R., Metal nanoparticles as green catalysts, Mater, 12(21), 3602(2019).

https://doi.org/10.3390/ma12213602

Narde, J., Ahmed, N., Maiti, S., Rajeshkumar, S. and Ganapathy, D., Green synthesis of silver nanoparticles from Aloe vera and Neem leaf extract and their cytotoxic effect evaluation, J. Popul. Ther. Clin. Pharmacol., 30, 174–180(2023).

https://doi.org/10.47750/jptcp.2023.30.12.020

Naseer, M., Aslam, U., Khalid, B. and Chen, B., Green route to synthesize zinc oxide nanoparticles using leaf extracts of Cassia fistula and Melia azedarach and their antibacterial potential, Sci. Rep., 10(1), 9055(2020).

https://doi.org/10.1038/s41598-020-65949-3

Naz, M., Haider, A., Ikram, M., Qureshi, M. Z. and Ali, S., Green synthesis (Azadirachta indica seed extract) of silver nanoparticles (Ag-NPs), characterization, their catalytic and bactericidal action potential, Nanosci. Nanotechnol. Lett., 9(11), 1649–1655(2017).

https://doi.org/10.1166/NNL.2017.2517

Neumark, G., Gong, Y. and Kuskovsky, I., Doping aspects of Zn-based wide-band-gap semiconductors. In Springer Handbook of Electronic and Photonic Materials Springer 843-854(2007).

https://doi.org/10.1007/978-0-387-29185-7_35

Newmaster, S. G., Grguric, M., Shanmughanandhan, D., Ramalingam, S. and Ragupathy, S., DNA barcoding detects contamination and substitution in North American herbal products, BMC Med, 11, 1–13(2013).

https://doi.org/10.1186/1741-7015-11-222

Nilavukkarasi, M., Vijayakumar, S. and Prathipkumar, S., Capparis zeylanica-mediated bio-synthesized ZnO nanoparticles as antimicrobial, photocatalytic and anti-cancer applications, Mater. Sci. Energy. Technol., 3, 335–343(2020).

https://doi.org/10.1016/j.mset.2019.12.004

Nur Diyana, S. Z., Nurul Izza Taib, N. I. T., Famiza Abdul Latif, F. A. L. and Zakiah Mohamed, Z. M., Utilization of Neem leaf extract on biosynthesis of iron oxide nanoparticles, Mol., 24(20), 3803(2019).

https://doi.org/10.3390/molecules24203803

Ogunyemi, S. O., Abdallah, Y., Zhang, M., Fouad, H., Hong, X., Ibrahim, E., Masum, M. M. I., Hossain, A., Mo, J. and Li, B., Green synthesis of zinc oxide nanoparticles using different plant extracts and their antibacterial activity against Xanthomonas oryzae pv. oryzae. Artificial Cells, Nanomed. Biotechnol., 47(1), 341–352(2019).

https://doi.org/10.1080/21691401.2018.1557671

Panahi, K. M., Salavati-Niasari, M. and Hosseinpour-Mashkani, S. M., Facile microwave synthesis, characterization, and solar cell application of selenium nanoparticles, J. Alloys. Compd., 617, 627–632(2014).

http://dx.doi.org/10.1016/j.jallcom.2014.07.174

Patel, J., Kumar, G. S., Roy, H., Maddiboyina, B., Leporatti, S. and Bohara, R. A., From nature to nanomedicine: Bioengineered metallic nanoparticles bridge the gap for medical applications, Disc. Nano, 19(1), 85(2024).

https://doi.org/10.1186/s11671-024-04021-9

Paul, R., Prasad, M. and Sah, N. K., Anticancer biology of Azadirachta indica L., (neem): A mini review, Cancer. Biol. Ther., 12(6), 467–476(2011).

https://doi.org/10.4161/cbt.12.6.16850

Pingale, S. S., Rupanar, S. V. and Chaskar, M., Plant-mediated biosynthesis of silver nanoparticles from Gymnema sylvestre and their use in photodegradation of methyl orange dye, J. Water. Environ. Nanotechnol., 3(2), 106–115(2018).

https://doi.org/10.22090/jwent.2018.02.002

Probst, C. E., Zrazhevskiy, P., Bagalkot, V. and Gao, ., Quantum dots as a platform for nanoparticle drug delivery vehicle design, Adv. Drug. Delivery. Rev., 65(5), 703–718(2013).

https://doi.org/10.1016/j.addr.2012.09.036

Pyrzynska, K. and Sentkowska, A., Biosynthesis of selenium nanoparticles using plant extracts, J. Nanostruct. Chem., 12, 467-480(2021).

https://doi.org/10.1007/s40097-021-00435-4

Quintana, M., Haro-Poniatowski, E., Morales, J. and Batina, N., Synthesis of selenium nanoparticles by pulsed laser ablation, Appl. Surf. Sci., 195(1–4), 175–186(2002).

https://doi.org/10.1016/S0169-4332(02)00549-4

Rajkumar, P. V., Prakasam, A., Rajeshkumar, S., Gomathi, M., Anbarasan, P. M. and Chandrasekaran, R., Green synthesis of silver nanoparticles using Gymnema sylvestre leaf extract and evaluation of its antibacterial activity, South Afr. J. Chem. Eng., 32(1), 1–4(2020).

https://doi.org/10.1016/j.sajce.2019.11.005

Ramamurthy, C. H., Sampath, K. S., Arunkumar, P., Kumar, M. S., Sujatha, V., Premkumar, K. and Thirunavukkarasu, C., Green synthesis and characterization of selenium nanoparticles and its augmented cytotoxicity with doxorubicin on cancer cells, Bioprocess. Biosyst. Eng, 36, 1131–1139(2013).

https://doi.org/10.1007/s00449-012-0867-1

Rasli, N. I., Basri, H. and Harun, Z., Zinc oxide from Aloe vera extract: Two-level factorial screening of biosynthesis parameters, Heliyon., 6(1), e03104(2020).

https://doi.org/10.1016/j.heliyon.2020.e03156

Rasool, S., Raza, M. A., Manzoor, F., Kanwal, Z., Riaz, S., Iqbal, M. J. and Naseem, S., Biosynthesis, characterization and anti-dengue vector activity of silver nanoparticles prepared from Azadirachta indica and Citrullus colocynthis, R. Soc. Open. Sci., 7(9), 200540(2020).

https://doi.org/10.1098/rsos.200540

Rauf, M. A., Owais, M., Rajpoot, R., Ahmad, F., Khan, N. and Zubair, S., Biomimetically synthesized ZnO nanoparticles attain potent antibacterial activity against less susceptible S. aureus skin infection in experimental animals, RSC. Adv., 7(58), 36361–36373(2017).

https://doi.org/10.1039/C7RA05040B

Reddy, B. and Bandi, R., Synthesis of selenium nanoparticles by using microorganisms and agri-based products, Agri-Waste and Microbes for Production of Sustainable Nanomaterials, Elsevier, 655–683(2022).

http://dx.doi.org/10.1016/B978-0-12-823575-1.00016-0

Reddy, I. V. and Neelima, P., Neem (Azadirachta indica): A review on medicinal Kalpavriksha, Int. J. Econ. Plants., 9(1), 59–63(2022).

http://dx.doi.org/10.23910/2/2021.0437d

Rehana, D., Mahendiran, D., Kumar, R. S. and Rahiman, A. K., In vitro antioxidant and antidiabetic activities of zinc oxide nanoparticles synthesized using different plant extracts, Bioprocess. Biosyst. Eng., 40(6), 943–957(2017).

https://doi.org/10.1007/s00449-017-1758-2

Rehman, G., Umar, M., Shah, N., Hamayun, M., Ali, A., Khan, W., Khan, A., Ahmad, S., Alrefaei, A. F., Almutairi, M. H. and Moon, Y. S., Green synthesis and characterization of silver nanoparticles using Azadirachta indica seeds extract: in vitro and in vivo evaluation of anti-diabetic activity, Pharm., 16(12), 1677(2023).

https://doi.org/10.3390/ph16121677

Rezazadeh, N. H., Buazar, F. and Matroodi, S., Synergistic effects of combinatorial chitosan and polyphenol biomolecules on enhanced antibacterial activity of biofunctionalized silver nanoparticles, Sci. Rep., 10(1), 19615(2020).

https://doi.org/10.1038/s41598-020-76726-7

Roy, P., Das, B., Mohanty, A. and Mohapatra, S., Green synthesis of silver nanoparticles using Azadirachta indica leaf extract and its antimicrobial study, Appl. Nanosci., 7(8), 843–850(2017).

https://doi.org/10.1007/s13204-017-0621-8

Narang, J. K., Baboota, S. and Ali, J., Promising role of nanopharmaceuticals in drug delivery, Pharm. Times., 43(10), 16–18(2011).

Seetharaman, P. K., Ramalingam, P., Chandrika, M., Rajan, R., Chelliah, J. and Liu, B., Antidiabetic potential of Gymnemic acid mediated gold nanoparticles (Gym@AuNPs) on Streptozotocin-induced diabetic rats—An implication on in vivo approach, Int. J. Pharm., 636, 122843(2023).

https://doi.org/10.1016/j.ijpharm.2023.122843

Segovia, M., Sotomayor, C., Gonzalez, G. and Benavente, E., Zinc oxide nanostructures by solvothermal synthesis, Mol. Cryst. Liq. Cryst., 555(1), 40–50(2012).

https://doi.org/10.1080/15421406.2012.634363

Shah, M., Fawcett, D., Sharma, S., Tripathy, S. K. and Poinern, G. E. J., Green synthesis of metallic nanoparticles via biological entities, Mater., 8(11), 7278–7308(2015).

https://doi.org/10.3390/ma8115377

Shahbaz, M., Akram, A., Raja, N. I., Mukhtar, T., Mehak, A., Fatima, N., Ajmal, M., Ali, K., Mustafa, N. and Abasi, F., Antifungal activity of green synthesized selenium nanoparticles and their effect on physiological, biochemical, and antioxidant defense system of mango under mango malformation disease, PLoS. One., 18(2), e0274679(2023).

https://doi.org/10.1371/journal.pone.0274679

Shanker, K., Mohan, G. K., Mayasa, V. and Pravallika, L., Antihyperglycemic and anti-hyperlipidemic effect of biologically synthesized silver nanoparticles and G. sylvestre extract on streptozotocin induced diabetic rats—an in vivo approach, Mater. Lett., 195, 240–244(2017).

http://dx.doi.org/10.1016/j.matlet.2017.02.137

Sharma, B. K., Shah, D. V. and Roy, D. R., Green synthesis of CuO nanoparticles using Azadirachta indica and its antibacterial activity for medicinal applications, Mater. Res. Express, 5(9), 095033(2018).

http://dx.doi.org/10.1088/2053-1591/aad91d

Shoeibi, S. and Mashreghi, M., Biosynthesis of selenium nanoparticles using Enterococcus faecalis and evaluation of their antibacterial activities, J. Trace. Ele. Med. Biol., 39, 135–139(2017).

https://doi.org/10.1016/j.jtemb.2016.09.003

Singh, B. N., Rawat, A. K. S., Khan, W., Naqvi, A. H. and Singh, B. R., Biosynthesis of stable antioxidant ZnO nanoparticles by Pseudomonas aeruginosa rhamnolipids, PLoS. One., 9(9), e106937(2014).

https://doi.org/10.1371/journal.pone.0106937

Singh, J., Dutta, T., Kim, K. H., Rawat, M., Samddar, P. and Kumar, P., ‘Green’ synthesis of metals and their oxide nanoparticles: Applications for environmental remediation, J. Nanobiotechnol., 16(1), 84(2018).

https://doi.org/10.1186/s12951-018-0408-4

Singh, S. C., Mishra, S. K., Srivastava, R. K. and Gopal, R., Optical properties of selenium quantum dots produced with laser irradiation of water suspended Se nanoparticles, J. Phys. Chem., 114(41), 17374–17384(2010).

Sinsheimer, J. E., Rao, G. S. and McIlhenny, H. M., (1970). Constituents from Gymnema sylvestre leaves V: isolation and preliminary characterization of the gymnemic acids. Journal of Pharmaceutical Sciences, 59(5), 622–628.

http://dx.doi.org/10.1021/jp105037w

Sohail, M. F., Rehman, M., Hussain, S. Z., Huma, Z. E., Shahnaz, G., Qureshi, O. S., Khalid, Q., Mirza, S., Hussain, I. and Webster, T. J., Green synthesis of zinc oxide nanoparticles by Neem extract as multi-facet therapeutic agents, J. Drug. Delivery. Sci. Technol., 59, 101911(2020).

https://doi.org/10.1016/j.jddst.2020.101911

Srividya, A. R., Varma, S. K., Dhanapal, S. P., Vadivelan, R. and Vijayan, P., In vitro and in vivo evaluation of hepatoprotective activity of Gymnema sylvestre, Int. J. Pharm. Sci. Nanotechnol.,, 2(4), 768–773(2009).

https://doi.org/10.37285/ijpsn.2009.2.4.12

Su, C., Liu, Y., He, Y. and Gu, J., Analytical methods for investigating in vivo fate of nanoliposomes: A review, J. Pharm. Anal., 8(4), 219–225(2018).

https://doi.org/10.1016/j.jpha.2018.07.002

Subapriya, R. and Nagini, S., Medicinal properties of neem leaves: a review, Curr. Med. Chem. Anti-Cancer. Agents., 5(2), 149–156(2005).

https://doi.org/10.2174/1568011053174828

Sun, Z., Li, Y., Gu, X., Wang, L., Yu, B., Yang, X. and Xu, H., Development of icariside II loaded polymeric micelles and evaluation of anticancer activity in vitro and in vivo, J. Drug. Delivery. Sci. Technol., 75, 103652(2022).

https://dx.doi.org/10.2139/ssrn.4153266

Supraja, N., Avinash, B. and Prasad, T. N. V. K. V., Green synthesis and characterization of silver nanoparticles from Gymnema sylvestre leaf extract: Study of antimicrobial activities, Int. J. Curr. Microbiol. Appl. Sci., 6(3), 530–540(2017).

https://doi.org/10.20546/ijcmas.2017.603.062

Suresh, D., Shobharani, R. M., Nethravathi, P. C., Kumar, M. P., Nagabhushana, H. and Sharma, S. C., Artocarpus gomezianus aided green synthesis of ZnO nanoparticles: Luminescence, photocatalytic and antioxidant properties, Spectrochim. Acta. Part A: Mol. Biomol. Spectros., 141, 128–134(2015).

http://dx.doi.org/10.1016/j.saa.2015.01.048

Sushruta., The Sushruta Samhita, Calcutta: Bharat Granthaghar (1907).

Suwanboon, S. J. S. A., Structural and optical properties of nanocrystalline ZnO powder from sol-gel method, Sci. Asia., 34(1), 31–34(2008).

http://dx.doi.org/10.2306/scienceasia1513-1874.2008.34.031

Tim, B., Błaszkiewicz, P., & Kotkowiak, M., Recent advances in metallic nanoparticle assemblies for surface-enhanced spectroscopy. International Journal of Molecular Sciences, 23(1), 291 (2021).

Tiwari, P., Mishra, B. N. and Sangwan, N. S., Phytochemical and pharmacological properties of Gymnema sylvestre: an important medicinal plant, BioMed. Res. Int., 2014, 830285(2014).

https://doi.org/10.1155/2014/830285

Tran, P. A. and Webster, T. J., Selenium nanoparticles inhibit Staphylococcus aureus growth, Int. J. Nanomed., 1553–1558(2011).

https://doi.org/10.2147/ijn.s21729

Ungvári, É., Monori, I., Megyeri, A., Csiki, Z., Prokisch, J., Sztrik, A., Jávor, A. and Benkő, I., Protective effects of meat from lambs on selenium nanoparticle supplemented diet in a mouse model of polycyclic aromatic hydrocarbon-induced immunotoxicity, Food. Chem. Toxicol., 64, 298–306(2014).

https://doi.org/10.1016/j.fct.2013.12.004

Van Overschelde, O., Guisbiers, G. and Snyders, R., Green synthesis of selenium nanoparticles by excimer pulsed laser ablation in water, APL. Mater., 1(4) (2013).

https://doi.org/10.1063/1.4824148

Verma, A. and Mehata, M. S., Controllable synthesis of silver nanoparticles using Neem leaves and their antimicrobial activity, J. Radiat. Res. Appl. Sci., 9(1), 109–115(2016).

https://doi.org/10.1016/j.jrras.2015.11.001

Wang, H., Zhang, J. and Yu, H., Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice, Free. Radic. Biol. Med., 42(10), 1524–1533(2007).

https://doi.org/10.1016/j.freeradbiomed.2007.02.013

Wu, Q. H., ZnO nanostructures prepared using a vapour transport method, J. Exp. Nanosci., 10(3), 161–166(2015).

https://doi.org/10.1080/17458080.2013.809559

Xulu, J. H., Ndongwe, T., Ezealisiji, K. M., Tembu, V. J., Mncwangi, N. P., Witika, B. A., & Siwe-Noundou, X.. The use of medicinal plant-derived metallic nanoparticles in theranostics. Pharmaceutics, 14(11), 2437 (2022).

Yadav, D., Suri, S., Choudhary, A., Sikender, M., Hemant, H., Beg, M. N., Garg, V., Ahmad, A. and Asif, M., Novel approach: Herbal remedies and natural products in pharmaceutical science as nano drug delivery systems, Int. J. Pharm. Technol., 3(3), 3092-31116(2011).

Yadav, R. N. S. and Agarwala, M., Phytochemical analysis of some medicinal plants, J. Phytol., 3(12) (2011).

Yadeta, G. L. and Lealem Birhanu, A., Green synthesis of ZnO, CuO and NiO nanoparticles using Neem leaf extract and comparing their photocatalytic activity under solar irradiation, Green. Chem. Lett. Rev., 17(1), 2293841(2024).

https://doi.org/10.1080/17518253.2023.2293841

Yan, Y., Warren, S. C., Fuller, P. and Grzybowski, B. A., Chemoelectronic circuits based on metal nanoparticles, Nat. Nanotechnol., 11(7), 603–608(2016).

https://doi.org/10.1038/nnano.2016.39

Zambri, N. D. S., Taib, N. I., Abdul Latif, F. and Mohamed, Z., Utilization of neem leaf extract on biosynthesis of iron oxide nanoparticles, Mol., 24(20), 3803(2019).

https://doi.org/10.3390/molecules24203803

Zhang, Q. W., Lin, L. G. and Ye, W. C., Techniques for extraction and isolation of natural products: A comprehensive review, Chinese. Med., 13, 1–26(2018).

https://doi.org/10.1186/s13020-018-0177-x

Zheng, S., Li, X., Zhang, Y., Xie, Q., Wong, Y. S., Zheng, W. and Chen, T., PEG-nanolized ultrasmall selenium nanoparticles overcome drug resistance in hepatocellular carcinoma HepG2 cells through induction of mitochondria dysfunction, Int. J. Nanomed., 3939–3949(2012).

https://doi.org/10.2147/ijn.s30940

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