Open Access

Designing and Synthesis of N-(6-phenylpyridin-2-yl) Pyridine-2-amine Derivatives as a Novel Antimicrobial Agent

Madhav S. Mane, P.G. Department of Chemistry and Research Center, S.C.S. College, Omerga, India Sandeep Gavade, P.G. Department of Chemistry and Research Center, S.C.S. College, Omerga, India Dhananjay V. Mane* dr_dvmane@rediffmail.com
P.G. Department of Chemistry and Research Center, S.C.S. College, Omerga, India

---

---

Abstract

A new series of N-(-6-phenylpyridin-2-yl) pyridine-2-amine derivatives were synthesized in satisfactory yield, through simple and greener methodology using 2-Amino, 6-Chloro, Pyridines as a starting material. Some of the newly prepared compounds demonstrate potent inhibitory activity against Gram positive bacteria, Gram negative bacteria and fungai. The results are discussed in terms of structure-activity relationships and an attempt was made to define the structural features required for activity.

Full Text

Reference

---

Alaa, A. and Abdel-Aziz, Lewis acid-promoted transformation of 2-alkoxypyridines into 2-aminopyridines and their antibacterial activity. Part 2: Remarkably facile C–N bond formation, Biorganic medicinal Chemistry,13(16), 4929-4935 (2005).

Barré-Sinoussi, F., Chermann, J. C., Rey, F., Nugeyre, M. T., Chamaret, S. and Gruest, J., Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS), Science Magazine, 220(4599), 868-871 (1983).

doi:10.1126/science.6189183

Popovic, M., Sarin, P. S., Robert-Gurroff, M., Kalyanaraman, V. S., Mann, D. and Minowada, J. Isolation and transmission of human retrovirus (human t-cell leukemia virus), Science Magazine, 219(4586), 856-859 (1983).

doi:10.1126/science.6600519

Mitsuya, H., Popovic, M., Yarchoan, R., Matsushita, S., Gallo, R. C. and Broder, S., Suramin protection of T cells in vitro against infectivity and cytopathic effect of HTLV-III, Science Magazine, 226, 172-174 (1984).

doi:10.1126/science.6091268