Open Access

Synthesis of Cobalt (II), Nickel(II), Copper(II) and Zinc(II) Complexes of N-(1-Morpholinosalicylyl)benzohydrazide and their Antimicrobial activities

M. Shanmugapriya, priyarajagopal10@gmail.com
Department of Chemistry, H.H.The Rajahs College, Pudukkottai, TN, India A. Rizwan Sulthana, Department of Chemistry, H.H.The Rajahs College, Pudukkottai, TN, India A. Abdul Jameel, Department of Chemistry, Jamal Mohamed College,Tiruchirapalli, TN, India M. Syed Ali Padusha Department of Chemistry, Jamal Mohamed College, Tiruchirapalli, TN, India

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Abstract

A new Mannich base, N-(1-Morpholinosalicylyl)benzohydrazide (MSB), formed by the condensation of morpholine, benzohydrazide and salicylaldehyde and its Co(II), Ni(II) Cu(II) and Zn(II) complexes have been synthesised. Their structures have been elucidated on the basis of analytical, magnetic, electrical conductivity and spectral methods. On the basis of colour,magnetic moments and spectral data, the geometries of Co(II), Ni(II), Cu(II) and Zn(II) complexes have been assigned. The electrochemical property of the ligand and its complexes in acetonitrile solution was studied by cyclic voltammetry. The X-band ESR spectra of the Cu(II) complex in DMSO at 300 and 77 K were recorded and their salient features are reported. Antibacterial activities of the ligand and its complexes were tested against some selected bacteria. The ligand and all the complexes showed antimicrobial activities.

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Reference

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Albert cotton, F., Geoffrey Wilkinson., Carlos Murillo A., Manfred Bochmann., Advanced Inorg.Chem., 6th edition, 841 (1999).

Cleare, M. J., Transition metal complexes in cancer chemotherapy, Coord. Chem. Rev. 12, 349 (1974). 

http://dx.doi.org/10.1016/S0010-8545(00)82029-9

Desai, P. S. and Desai, K. R., J. Indian Chem.Soc., 70, 177 (1993).

Figgis, B. N. and Nyholm, R. S., The temperature-dependence of the magnetic susceptibility of bivalent cobalt compounds,  J.Chem.Soc., 338 (1959). 

http://dx.doi.org/10.1039/jr9590000338

Haidue, L., Metal compounds in cancer chemotherapy, Coord. Chem. Rev. 99, 253 (1990).

http://dx.doi.org/10.1016/0010-8545(90)80065-2

Jameel, A. A. and Padusha, M. S. A., Synthesis and biological activities of some new mannich bases of furfural, Indian J. Heterocycl. chem., 16, 197 (2006).

Kasim, A. N. M., Venkappayya, D. and Prabhu, G. V., J. Indian Chem. Soc., 76, 67 (1999).

Lever, A. B. P and Mantovani, E., Far-infrared and electronic spectra of some bis(ethylenediamine) and related complexes of copper(II) and the relevance of these data to tetragonal distortion and bond strengths, Inorg. Chem., 10, 817 (1971). 

http://dx.doi.org/10.1021/ic50098a031

Narang, K. K. and Agarwal, A., Salicylaldehyde salicylhydrazone complexes of some transition metal ions, Inorg. Chem. Acta, 9, 137 (1974). 

http://dx.doi.org/10.1016/S0020-1693(00)89895-3

Raman, N. and Ravichandran, S., Effect of Substituents on N-(1-Piperidinobenzyl)acetamide and N-(1-Morpholinobenzyl)acetamide and Their Antimicrobial Activity, Asian, J., Chem., 15, 1848-1850 (2003).

Reddy, K.R., Reddy, K. M. and Mahendran, K. N., Indian J.Chem., 45A, 378 (2006).

Singh, B., Singh, R. N. and Aggarwal, R. C., Magnetic and spectral studies on N-(thiophene-2-carboxamido)salicylaldimine complexes of some bivalent 3dmetal ions, Polyhedron 4, 401 (1985). 

http://dx.doi.org/10.1016/S0277-5387(00)86999-5

Shanmugapriya, M., Abdul Jameel, A.and Syed Ali Padusha, M., Synthesis, characterization and antimicrobial activities of salicylaldehyde derivatives. International J. Chem. Tech Research 12-15, 4 (2012).

Srivastava, R. S., Pseudotetrahedral Co(II), Ni(II) and Cu(II) complexes of N1-(O-chlorophenyl)-2-(2′,4′-dihydroxyphenyl)-2-benzylazomethine their fungicidal and herbicidal activity, Inorg. Chem. Acta 56, 65 (1944). 

http://dx.doi.org/10.1016/S0020-1693(00)88534-5

Zotta, V., Chimie farmaceutic, Ed. Medical, Bucureti, (1985).