Welcome to JENT its Monday 22nd of January 2018

Journal of Environmental Nanotechnology

(A Quarterly Peer-reviewed and Refereed International Journal)
ISSN(Print):2279-07 48; ISSN(Online):2319-5541

Synthesis of 2-Methyl -3,4,5,10-Tetrahydro-Pyrrolo [3,2-A] Carbazole-Ethyl Carboxylate Derivatives and Evaluation of their Binding Affinity with CT-DNA


A new class of heterocyclic compound, substituted 2-methyl-3,4,5,10-tetarahydro-pyrrolo[3,2- a]carbazole-1-ethyl carboxylate derivatives have been prepared from 1-oxo-1,2,3,4,-tetrahydrocarbazoles. The structural features were determined by analytical and spectral techniques. DNA binding study of the compounds was investigated by absorption titration experiments which indicated that the compounds showed good binding affinity to CT-DNA via intercalation.

Article Type: Research Article

Corresponding Author: M. Sekar 3  

Email: mmsekar7@gmail.com

This article has not yet been cited.

M. Saravanabhavan 1,  V. Murugesan 2,  M. Sekar 3*.  

1, 2, 3. Department of Chemistry, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore, TN, India.

J. Environ. Nanotechnol. Volume 2, No.4 pp.62-67
ISSN: 2279-0748 eISSN: 2319-5541
Download Citation


Auclair,  C.,  Multimodal  action  of  antitumor agents on DNA: The ellipticine series,  Arch.
Biochem. Biophys.,1, 259112:1-14(1987). http://h t t p :/ / d x . d o i. o r g / 1 0 . 1 0 1 6 / 0 0 0 3 -9861(87)90463-2.
Jain, S. C., Bhandary, K. K., Sobbell, H. M., Visualization  of  drug—nucleic  acid
interactions  at  atomic  resolution.  VI. Structure  of  two  drug—dinucleoside
monophosphate  crystalline  complexes, ellipticine—5-iodocytidylyy  (3'-5') guanosine  and  3,5,6,8-tetramethyl-Nmethyl  phenanthrolinium—5-iodocytidylyl (3'-5') guanosine,  J. Mol. Biol.,135, 813-84(1979). http://dx.doi.org/10.1016/0022-2836(79)90514-X.

Monnot, M., Mauffret, O., Simon, V., Lescot, E., Psaume, B., Saucier, J. M., DNA-drug
recognition  and  effects  on  topoisomerase II-mediated  cytotoxicity. A  three-mode
binding  model  for  ellipticine  derivatives., J. Biol. Chem.,25, 1820-1829(1991).

Singh, M. P., Hill, G. C., Peoch, D., Rayner, B., Inabach, J. L., Lown, J. W., High-Field
NMR and Restrained Molecular Modeling Studies on a DNA Heteroduplex Containing
a  Modified Apurinic Abasic  Site  in  the Form  of  Covalently  Linked  9-Aminoellipticine,  Biochemistry.,  33, 10271-10285(1994). http://http://dx.doi.org/ 10.1021/bi00200a007.

Viji, M., Nagarajan, R., RuCl3/SnCl2 mediated synthesis  of  pyrrolo[2,3-c]carbazoles  and
consequent  preparation  of  indolo[2,3-c]carbazoles,  Tetrahedron., 68,   2453-2458(2012). http://http://dx.doi.org/10.1016/j.tet.2012.01.070.

Vogel, A.  I.,  Text  book  of  practical  organic chemistry,Longman, London, (1989).
Wolfe,  A.,  Shimer,  G.  H.,  Meehan,  T., Polycyclic  aromatic  hydrocar bons
physically  intercalate  into  duplex  regions of  denatured  DNA,  Biochemistry., 26,
6392-6396(1987).  http://dx.doi.org/10.1021/bi00394a013.

Yamuna,  E., Ajay  Kumar,  R.,  Zellar,  M., Rajandra  Prasad,  K.  J.,  Synthesis,
antimicrobial,  antimycobacterial  and structure–activity  relationship  of substituted pyrazolo-, isoxazolo-, pyrimidoand  mercaptopyrimido  cyclohepta [b]indoles,  Eur.  J. Med.  Chem.,47,  228-238(2012).  http://dx.doi.org/10.1016/j.ejmech.2011.10.046.

Yamuna, E., Zellar, M., Rajandra Prasad, K. J.,  Syntheses  of  indolo  [3,2,1-d,e]
phenanthridines  and  isochromeno[3,4-a] carbazoles:  palladium  catalyzed
intr amolecular  arylation  via  C–H functionalization,  Tetrahedron.,52, 6030-6034(2011). http://dx.doi.org/10.1016/j.tetlet.2011.09.018.